ARDSNet
LaSRS
Late Steroid Rescue Study
Submitted by Nancy Ringwood on Mon, 2011-06-06 13:18The late phase of ARDS is often characterized by excessive fibroproliferation leading to gas exchange and compliance abnormalities. The objective of the LaSRS study was to determine if the administration of corticosteroids, in the form of methylprednisolone sodium succinate, in severe late-phase ARDS, would have a positive effect on this fibroproliferation, thereby reducing mortality and morbidity.
Late Steroid Rescue Study
The late phase of ARDS is often characterized by excessive fibroproliferation leading to gas exchange and compliance abnormalities. The objective of the LaSRS study was to determine if the administration of corticosteroids, in the form of methylprednisolone sodium succinate, in severe late-phase ARDS, would have a positive effect on this fibroproliferation, thereby reducing mortality and morbidity.
The results were published in: Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome Steinberg, KP; Hudson, LD; Goodman, RB; Hough, CL; Lanken, PN; Hyzy, R; Thompson, BT; Ancukiewicz, M; NIH / NHLBI ARDSNet, New Engl J Med, May 25, Volume 354, Issue 16, p.1671-1684, (2006)
LaSRS Study Synopsis
The Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome
