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ARMA

Lower Tidal Volume Trial

Study status: Completed
Study dates: Mar 1996 — Jul 1999

The ARMA study was a randomized, controlled multi-center 2 x 2 factorial study consisting of a drug treatment (Ketoconazole vs. placebo) and a ventilation strategy (6ml/kg tidal volume vs. 12ml/kg tidal volume).

The ventilator arm of the protocol was designed to compare different ventilator strategies and their effect on mortality and morbidity. The lower tidal volume strategy (6 ml/kg) improved survival and the study was stopped early. The drug arm of the protocol, Ketoconazole did not show promise and was subsequently stopped.

Lower Tidal Volume / Higher PEEP Reference Card

Mechanical ventilation protocol summary of low tidal volume used in the ALVEOLI study.

Predicted Body Weight Calculator

Tidal volumes for the ARMA study were based on predicted body weight (PBW). This is a calculation based on gender and height. The following are reference tables with PBW calculated for 4-8ml tidal volumes for males and females.

Formula: Males: PBW (kg) = 50 + 2.3 (height (in) – 60); Females: PBW (kg) = 45.5 + 2.3 (height (in) – 60)

ARMA Study Synopsis

Prospective, Randomized, Multi-Center Trial of 12ml/kg Tidal Volume Positive Pressure Ventilation for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome (ARMA)

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