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Lower Tidal Volume Trial

Lower Tidal Volume Trial

Study status: Completed
Study dates: Mar 1996 — Jul 1999

The ARMA study was a randomized, controlled multi-center 2 x 2 factorial study consisting of a drug treatment (Ketoconazole vs. placebo) and a ventilation strategy (6ml/kg tidal volume vs. 12ml/kg tidal volume).

The ventilator arm of the protocol was designed to compare different ventilator strategies and their effect on mortality and morbidity. The lower tidal volume strategy (6 ml/kg) improved survival and the study was stopped early. The drug arm of the protocol, Ketoconazole did not show promise and was subsequently stopped.

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